Fire investigators believe the old Keystone Pharmacy building at 73rd and Maple is a total loss.
Crews responded to an alarm at 11 p.m. Sunday night, and found heavy smoke and flames coming from the building.
As crews battled the fire, they were pulled back to a defensive position when the roof and walls started to collapse.
Fire Chief Bernie Kanger said there was a lot of material inside the building for the fire to go through, and the entire structure is considered a total loss.
Investigators believe the building and contents were valued just under $1 million dollars.
Ariel view below from Omaha Police "Able One" helicopter.